The mean change versus the baseline level was significantly different between the groups at day 2, 4, 7, and 14 and no longer different from day 25. The 25(OH)D 3 serum concentrations from baseline to day 75 were 14.3 ± 3.7 to 27.8 ± 3.9 ng/mL in the monthly group and 14.1 ± 3.4 to 28.8 ± 5.4 ng/mL in the daily group. The same cumulative dose of vitamin D 3 was given to each treatment group (150,000 IU). We randomized 60 subjects with vitamin D deficiency to receive 2000 IU vitamin D 3 daily or 50,000 IU monthly. This is a monocentric, two-armed, randomized, interventional, open, and parallel study conducted from November 2016 to March 2017 in Belgium. We aimed to determine whether a cumulative dose of vitamin D 3 produces the same effects on the serum concentration of 25(OH)D 3 if it is given daily or monthly.
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